Dr. Pearce is an expert in immunometabolism and holds appointments in the departments of Oncology and Molecular Microbiology and Immunology at the Johns Hopkins School of Medicine, as well as in the Bloomberg School of Public Health. Previously, he was senior group leader at the Max Planck Institute of Immunobiology and Epigenetics and a Professor in the Faculty of Biology at the University of Freiburg. His research interests focus on two overlapping research areas: understanding metabolic reprogramming for how immune cells are able to make changes in their metabolism, and Type 2 immunity which is induced by certain types of infection. His recent focus is on the role of cellular metabolism in immune cell function and fate during infection and cancer. He is particularly interested in understanding the relationship between metabolic reprogramming and differential cell activation and in identifying ways to inhibit or promote metabolic pathways to manipulate immune responses.
Dr. Pearce obtained his PhD for research on immunity to helminth parasites that he performed at NIMR, Mill Hill, London. He pursued postdoctoral training with Alan Sher at the NIH, where he focused on understanding Type 2 bias in immune responses during a variety of types of infection. Earlier in his career, Dr. Pearce held faculty positions at Cornell University, University of Pennsylvania, Trudeau Institute, Washington University School of Medicine