Targeting hubs of cellular metabolism to drive a shift in immune activity to treat disease
Since cellular metabolism is the set of the biochemical reactions undertaken to convert energy and nutrients into essential activities, it is central for the regulation of immune function. Immune cells are unique in that their metabolic activities vary widely depending on circumstances. For instance, there are coordinated and dramatic changes in activity across multiple immune cell subtypes during activation of the immune system, followed by resolution of that response after elimination of a threat. In autoimmune and inflammatory diseases, dysregulated activation and resolution have long been observed, but have not been systematically harnessed for discovery of novel medicines.
Metabolic hubs as the access point
Rheos is interrogating metabolic hubs that comprise the central orchestrated metabolic events controlling immune cell function. Metabolic hubs provide a coordinated access point for variations in immune cell metabolism that can lead to dysregulation of the immune system in autoimmune and inflammatory diseases, to advance our targeted and precision medicines. We have mapped four key metabolic hubs that open up broad opportunities for novel medicines. Each metabolic hub represents a group of molecular pathways essential in multiple immune cell subtypes to regulate their cellular metabolism and drive system-wide transition in immunologic function.
With our focus on metabolic hubs, Rheos has implemented a first-in-field approach that builds a comprehensive, systems-level understanding of the pathways that define the metabolic dysregulation and drive immune-mediated diseases. This approach powers our discoveries across the drug development continuum, from target identification through to molecular signatures of patient subsets.