Director, Immuno-oncology

Director, Immuno-oncology

Title:                     Director, Immuno-oncology
Department:      Biology        
Reports To:        Senior Director, Discovery Biology
Location:             Cambridge, MA

The Company:

At Rheos Medicines, we are pioneering in the emerging field of Immunometabolism to discover novel medicines to treat autoimmune diseases.

The Director, Immuno-oncology will manage a small group of scientists to support pre-clinical target discovery and validation efforts as well as develop translational strategies for our immuno-oncology programs. Key responsibilities of this role are to act as key strategic lead for the immune-oncology programs while working with cross-functional teams. In addition, management of laboratory scientists to generate data in support of clinical development decisions.


  • Maintains and conveys in-depth knowledge of fundamentals of immunology, immune oncology, and tumor biology in solid and hematological malignancies
  • Oversees scientists as a group lead and works with the Leadership team to ensure execution of in-vitro and ex-vivo assays to translate preclinical data into clinical biomarkers for advancing pre-clinical programs through drug-discovery stage gates.
  • Assists in developing and maintaining group budget and workforce plan
  • Represents pre-clinical and translational development in cross-functional project and strategy teams
  • Assists in managing key strategic and/or collaborative projects with external partners
  • Communicates regularly and prepares and makes presentations within the department, externally and to the company.
  • Works with lab head to integrate immune-oncology research into the overall corporate strategy at Rheos Medicines .


  • D. degree in immunology, tumor biology, cellular biology or pharmacology.
  • At least 10 years of relevant work experience, including a minimum of 5 years of drug development experience in the biotechnology or pharmaceutical industrial setting as evidenced by a strong publication record, attendance and presentation at scientific meetings, and recognition by industry peers.
  • Track record in large and small companies, leading innovative efforts to deploy technologies and assays for enhanced translational capabilities.
  • Excellent communication, managerial and scientific qualities are expected.
  • Ability to interact effectively across boundaries using influencing and relationship building skills.
  • Competence in analysis and solving of problems, and the ability to prioritize and make tradeoffs to achieve goals.

 Technical Skills

  • In-depth understanding of solid and hematological tumors, clinical landscape, evolving therapy, competitive scenario.
  • Strong understanding of clinical, translational and mechanistic data of cancer therapies.
  • Strong background in target discovery, pre-clinical validation, in vitro and in vivo platforms and assays.
  • A track record in developing and implementing biomarker strategy for clinical trials would be highly desired.
  • Good understanding of drug development process in an industry setting.
  • Strong verbal and written communication skills with experience in developing written documents such as primary manuscripts/publications/reviews, disease strategies, mechanism slides, literature/market/patient segment analyses.
  • Proven scientific/project leadership expertise (working in teams, managing collaborations, people/projects).
  • Ability to synthesize complex scientific and business problems into strategy and tactics.

Other Attributes

  • A problem solver who creatively and knowledgeably transcends departmental function to act as a resource to entire research effort.
  • Identifies issues early and proposes innovative solutions.
  • Communicates within the larger organization and external community.
  • Provides expert guidance to multi-disciplinary teams and senior management.
  • A leader who influences external scientific community.


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