Senior Scientist, Lead Discovery (Cell Biology)

Cambridge, MA
August 10, 2020

The Role

The Scientist II/Senior Scientist, Lead Discovery, will develop, implement, and execute appropriate cellular-based assays in support of drug discovery projects. The ideal candidate will utilize a diverse set of cellular immunology, biochemical, and metabolic techniques to profile small molecule chemical matter in support of lead projects.  The ability to work closely with contract resource organizations (CROs) to oversee experiments, analyze data, and report results will be required.


  • Effectively work in a matrixed organization while parallel processing several key activities simultaneously
  • Design and optimize cellular assays to evaluate small molecule inhibitors in support of drug discovery projects
  • Deliver results in a virtual environment until COVID-19 work from home restrictions are lifted
  • Generate and maintain relevant cell lines for compound profiling and screening    
  • Demonstrate target engagement of prioritized compounds in a cellular environment
  • Develop novel assays for biomarker identification
  • Manage CROs and oversee all aspects of the relationship
  • Generate SOP documents
  • Manage uploading of data to internal database
  • Work cross-functionally by communicating experimental results and conclusions within the Lead Discovery and Biology groups


  • Ph.D. in Cell and Molecular Biology (or Biochemistry) with 4 – 10 years industrial, drug discovery experience or a M.S./B.S. with 10+ years of experience
  • Experience in generating cellular reagents in support of cell-based activity assays
  • Experience in generating cell-based assays to enable lead optimization of small molecule inhibitors
  • Experience establishing cellular high-throughput and phenotypic screening assays in collaboration with CROs
  • Experience in designing and implementing cell-based assays at CROs
  • Experience in immunology or metabolism is a plus
  • Biochemical assay experience (mechanistic enzymology/high-throughput screening) is considered an advantage
  • Knowledge of the drug discovery process, with the ability to design, plan, and troubleshoot difficult problems in target engagement and biomarker assays
  • Can-do attitude and team player with strong organizational, interpersonal, verbal, and written communication skills
  • Ability to work effectively in a cross-functional matrix-based organization
  • Verbal and written communication skills and ability to parallel path multiple projects simultaneously

Apply Now

At Rheos we endeavor to create an environment where great people have the opportunity to do great things.  We are pioneering new science and that takes creativity, innovation, integration and lots of teamwork to solve complex challenges.  We are risk takers and desire that our work at Rheos creates a new paradigm for immune-mediated diseases.

A highlight of our current benefit offerings:

  • Highly competitive healthcare coverage through Blue Cross Blue Shield, dental coverage through Delta Dental and vision coverage through VSP.
  • 401k with match
  • Discretionary time off in addition to a 2 shutdowns per year (summer and winter) and additional company holidays
  • Complementary Long- and Short-Term Disability and Life Insurance
  • Monthly Cell Phone reimbursement
  • Free parking, monthly subway pass or subsidized commuter rail pass

Rheos Medicines is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Rheos Medicines complies with applicable state and local laws governing nondiscrimination in employment.


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