Director, Discovery Biology

Cambridge, MA
June 05, 2020

The Role

The Director, Discovery Biology will manage a small group of scientists to drive target discovery and validation efforts as well as develop translational strategies for our early programs. Key responsibilities of this role are to develop research strategies and execute on plans to evaluate and validate targets to modulate immune cell function. Working in cross-functional teams and management of laboratory scientists will be required to generate data in support of development decisions.


  • Maintains and conveys in-depth knowledge of fundamentals of immune mediated diseases
  • Oversees scientists as a group lead and works with the leadership team to ensure execution of in-vitro and in-vivo assays to validate new targets for advancement into portfolio and through drug-discovery stage gates
  • Assists in developing and maintaining group budget and workforce plan
  • Represents pre-clinical and translational development in cross-functional project and strategy teams
  • Assists in managing key strategic and/or collaborative projects with external partners
  • Communicates regularly and prepares and makes presentations within the department, externally, and to the company
  • Works with VP, Biology to integrate new target research into the overall corporate strategy


  • Ph.D. degree in immunology, cellular biology or pharmacology
  • At least 10 years of relevant work experience, including a minimum of 5 years of drug development experience in the biotechnology or pharmaceutical industrial setting as evidenced by a strong publication record, attendance and presentation at scientific meetings, and recognition by industry peers
  • Track record in large and small companies, leading innovative efforts to deploy technologies and assays for enhanced translational capabilities
  • Excellent communication, managerial, and scientific qualities are expected
  • Ability to interact effectively across boundaries using influencing and relationship building skills
  • Competence in analysis and solving of problems, and the ability to prioritize and make tradeoffs to achieve goals
  • Experience in cell signaling and/or cellular metabolism is a plus
  • In-depth understanding of autoimmune and inflammatory diseases, clinical landscape, evolving therapy, competitive scenario
  • Strong understanding of clinical, translational and mechanistic data of immunomodulatory therapies
  • Strong background in target discovery, pre-clinical validation, in vitro and in vivo platforms and assays
  • Good understanding of drug development process in an industry setting
  • Strong verbal and written communication skills with experience in developing written documents such as primary manuscripts/publications/reviews, disease strategies, mechanism slides, literature/market/patient segment analyses
  • Proven scientific/project leadership expertise (working in teams, managing collaborations, people/projects)
  • Ability to synthesize complex scientific and business problems into strategy and tactics
  • A problem solver who creatively and knowledgeably transcends departmental function to act as a resource to entire research effort
  • Identifies issues early and proposes innovative solutions
  • Communicates within the larger organization and external community
  • Provides expert guidance to multi-disciplinary teams and senior management
  • A leader who influences external scientific community

Apply Now

At Rheos we endeavor to create an environment where great people have the opportunity to do great things.  We are pioneering new science and that takes creativity, innovation, integration and lots of teamwork to solve complex challenges.  We are risk takers and desire that our work at Rheos creates a new paradigm for immune-mediated diseases.

A highlight of our current benefit offerings:

  • Highly competitive healthcare coverage through Blue Cross Blue Shield, dental coverage through Delta Dental and vision coverage through VSP.
  • 401k with match
  • Discretionary time off in addition to a 2 shutdowns per year (summer and winter) and additional company holidays
  • Complementary Long- and Short-Term Disability and Life Insurance
  • Monthly Cell Phone reimbursement
  • Free parking, monthly subway pass or subsidized commuter rail pass

Rheos Medicines is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Rheos Medicines complies with applicable state and local laws governing nondiscrimination in employment.


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