Principal Scientist, Medicinal Chemistry

Cambridge, MA
March 16, 2020

The Role

The Principal Scientist, Medicinal Chemistry will be working with our internal and external drug discovery groups to design and execute integrated medicinal chemistry strategies in the pursuit of target validation, hit-to-lead generation, lead optimization and clinical candidate selection. The successful candidate will design and prioritize medicinal chemistry plans and manage external chemistry teams to deliver small molecule development candidates. 


  • Be accountable for the design and execution of medicinal chemistry strategies that integrate aspects the entire drug R&D process – including target validation, hit finding, lead optimization, ADME/PK, pharmacology and toxicology - to successfully deliver development candidates
  • Effectively manage external medicinal chemistry teams, fee for service efforts and compound management needs
  • Communicate medicinal chemistry strategies, ideas and results to colleagues and management
  • Work collaboratively across diverse drug discovery functions and multidisciplinary project teams
  • Strongly contribute to the identification and prioritization of critical path activities to facilitate decision making and drive project progression
  • Actively follow and integrate scientific advancements within the area of research interest
  • Contribute to development and execution of a publication strategy, i.e. patents, medicinal chemistry literature and scientific presentations.


  • PhD in organic chemistry with 8+ years of drug discovery experience in a pharmaceutical/biotechnology setting
  • Strong knowledge of the drug discovery process, with deep experience in implementing strategies across all stages of medicinal chemistry from hit identification through to lead optimization
  • Prior experience acting as project or chemistry team lead with demonstrated success in delivering development candidates
  • Experience functioning as a go-to person within a strong multi-disciplinary, dynamic and highly matrixed environment and utilizing physicochemical, biochemical, ADME/PK, and pharmacological data to drive medicinal chemistry strategies
  • Very strong written and verbal communication skills
  • Experience in managing external chemistry teams to high levels of performance while maintaining a strong, supportive culture
  • Demonstrated technical/problem solving skills and scientific creativity in synthetic and medicinal chemistry as evidenced by a significant publication record, filed patents and/or presentations
  • Team player with strong organizational and interpersonal skills

Apply Now

At Rheos we endeavor to create an environment where great people have the opportunity to do great things.  We are pioneering new science and that takes creativity, innovation, integration and lots of teamwork to solve complex challenges.  We are risk takers and desire that our work at Rheos creates a new paradigm for immune-mediated diseases.

A highlight of our current benefit offerings:

  • Highly competitive healthcare coverage through Blue Cross Blue Shield, dental coverage through Delta Dental and vision coverage through VSP.
  • 401k with match
  • Discretionary time off in addition to a 2 shutdowns per year (summer and winter) and additional company holidays
  • Complementary Long- and Short-Term Disability and Life Insurance
  • Monthly Cell Phone reimbursement
  • Free parking, monthly subway pass or subsidized commuter rail pass

Rheos Medicines is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Rheos Medicines complies with applicable state and local laws governing nondiscrimination in employment.


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