Scientist, Lead Discovery (cell biology)

Cambridge, MA
March 11, 2020

The Role:

The Scientist, Lead Discovery, will develop, implement, and execute appropriate cellular-based assays in support of drug discovery projects. The ideal candidate will be required to utilize a diverse set of cellular immunology, biochemical, and metabolic techniques to support lead discovery and profile small molecule chemical matter.  They will be responsible for establishing and implementing project-based cellular target engagement assays and should have comprehensive knowledge of these techniques.


  • Ability to work in a matrixed organization while parallel processing several key activities simultaneously
  • Design and optimize cellular assays to evaluate small molecule inhibitors in support of drug discovery projects at Rheos
  • Generate and maintain relevant cell lines for compound profiling and screening   
  • Determine potential mechanism(s) of action for CRISPR screening hits  
  • Utilize molecular biology techniques to verify that catalytic activity is responsible for observed cellular phenotype
  • Demonstrate target engagement of prioritized compounds in a cellular environment
  • Generate SOP documents
  • Manage uploading of data to an internal database
  • Work cross-functionally by communicating experimental results and conclusions within the Lead Discovery and Biology groups


  • Either a PhD degree in cell and/or molecular biology with 3 – 5 years of drug discovery experience or a BS/MS degree with 10 – 15 years of experience
  • Knowledge of the drug discovery process with the ability to plan and troubleshoot difficult problems in cellular biology
  • Experience in generating cellular reagents in support of cell-based activity assays
  • Experience with developing cell-based assays to enable lead optimization of small molecules
  • Can-do attitude and team player with strong organizational,interpersonal, verbal and written communication skills
  • Experience in establishing cellular assays at contract research organizations (CROs)

Apply Now

At Rheos we endeavor to create an environment where great people have the opportunity to do great things.  We are pioneering new science and that takes creativity, innovation, integration and lots of teamwork to solve complex challenges.  We are risk takers and desire that our work at Rheos creates a new paradigm for immune-mediated diseases.

A highlight of our current benefit offerings:

  • Highly competitive healthcare coverage through Blue Cross Blue Shield, dental coverage through Delta Dental and vision coverage through VSP.
  • 401k with match
  • Discretionary time off in addition to a 2 shutdowns per year (summer and winter) and additional company holidays
  • Complementary Long- and Short-Term Disability and Life Insurance
  • Monthly Cell Phone reimbursement
  • Free parking, monthly subway pass or subsidized commuter rail pass

Rheos Medicines is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Rheos Medicines complies with applicable state and local laws governing nondiscrimination in employment.


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