Senior Research Associate / Associate Scientist, Biochemistry

Cambridge, MA
February 19, 2020

The Role

The Senior Research Associate/ Associate Scientist, Biochemist will provide essential support to small molecule drug discovery programs through the development and utilization of in vitro biochemical assays.  The ideal candidate will employ a variety of biochemical/biophysical techniques to develop enzymatic assays and validate small molecule chemical matter.


  • Ability to work in a matrixed organization while parallel processing several key activities simultaneously
  • Develop enzymatic assays to support Rheos’s drug discovery pipeline, including high-throughput screening and selectivity panels
  • Assess activity and substrate specificity for enzyme preparations     
  • Utilize biochemical/biophysical assays to prioritize/validate screening hits
  • Generate SOP documents
  • Manage uploading of data to an internal database


  • BS/MS degree with 5 – 10 years drug discovery experience in a pharmaceutical/biotechnology setting with a focus on biochemistry and mechanistic enzymology.
  • Cell biology assay experience (generation/optimization of cell assays to interrogate small molecule inhibitors) is considered an advantage
  • Knowledge of the drug discovery process, with the ability to plan and troubleshoot problems arising in biochemical assay development/screening.
  • Experience with implementing a variety of assay formats, such as TR-FRET, AlphaLISA, FP, Radiometric, Luminescence, Mass Spectrometry (RapidFire), etc.
  • Experience with external collaborations (CROs) is an advantage, but not required.
  • Can-do attitude and team player with strong organizational, interpersonal, verbal and written communication skills.

Apply Now

At Rheos we endeavor to create an environment where great people have the opportunity to do great things.  We are pioneering new science and that takes creativity, innovation, integration and lots of teamwork to solve complex challenges.  We are risk takers and desire that our work at Rheos creates a new paradigm for immune-mediated diseases.

A highlight of our current benefit offerings:

  • Highly competitive healthcare coverage through Blue Cross Blue Shield, dental coverage through Delta Dental and vision coverage through VSP.
  • 401k with match
  • Discretionary time off in addition to a 2 shutdowns per year (summer and winter) and additional company holidays
  • Complementary Long- and Short-Term Disability and Life Insurance
  • Monthly Cell Phone reimbursement
  • Free parking, monthly subway pass or subsidized commuter rail pass

Rheos Medicines is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Rheos Medicines complies with applicable state and local laws governing nondiscrimination in employment.


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