Principal Scientist / Associate Director, in vivo

Cambridge, MA
January 09, 2020

The Role:

The Principal Scientist/Associate Director, in vivo Biology will be responsible for development and execution of in vivo strategies to support pipeline programs. Key responsibilities of this role are to develop research strategies using a mechanistic understanding of in vivo inflammation and autoimmune models.  Working in cross-functional teams and management of external CRO workflows will be required to generate data in support of development decisions.

Primary Responsibilities:

  • Maintains and conveys in-depth knowledge of fundamentals of immune mediated diseases.
  • Oversees identification and coordination of CROs.  Manages data analyses and external communication.
  • Develops in vivo experimental plans with project teams to enable an understanding of mechanism of action and PK/PD relationships.
  • Assists in developing and maintaining budget and external workplans. 
  • Represents pre-clinical development in cross-functional project teams 
  • Assists in managing key strategic and/or collaborative projects with external partners
  • Communicates regularly and prepares and makes presentations within the department, to the company and externally.
  • Integrates new target research into the overall corporate strategy

Requirements and Qualifications:



  • Ph.D. degree in immunology or pharmacology.


Required Experience:

  • 8-10 years of relevant experience in vivo pharmacology, including a minimum of 5 years of drug development experience in the biotechnology or pharmaceutical industrial setting.
  • A strong publication record, attendance and presentation at scientific meetings, and track record of recognition by industry peers.
  • In-depth understanding of rodent models of autoimmune and inflammatory diseases.
  • Strong understanding of translational and mechanistic data of immunomodulatory therapies.
  • Background in in vivo pharmacology, PK/PD analyses in drug development.
  • Track record in large and small companies, leading innovative efforts to deploy technologies and assays for enhanced translational capabilities.


Knowledge, Skills & Abilities:

  • Excellent communication, managerial and scientific qualities
  • Ability to interact effectively across the organization using influencing and relationship building skills.
  • Competence in analysis and solving of problems, and the ability to prioritize and make tradeoffs to achieve goals.
  • Strong verbal and written communication skills with experience in developing written documents such as primary manuscripts/publications/reviews, disease strategies, mechanism slides, literature/market/patient segment analyses. 
  • Proven scientific/project leadership expertise (working in teams, managing collaborations, people/projects).
  • Ability to synthesize complex scientific and business problems into strategy and tactics.
  • A problem solver who creatively and knowledgeably transcends departmental function to act as a resource to entire research effort.
  • Identifies issues early and proposes innovative solutions.
  • Communicates within the larger organization and external community.
  • Provides expert guidance to multi-disciplinary teams and senior management.
  • A leader who influences external scientific community.


Apply Now

At Rheos we endeavor to create an environment where great people have the opportunity to do great things.  We are pioneering new science and that takes creativity, innovation, integration and lots of teamwork to solve complex challenges.  We are risk takers and desire that our work at Rheos creates a new paradigm for immune-mediated diseases.

A highlight of our current benefit offerings:

  • Highly competitive healthcare coverage through Blue Cross Blue Shield, dental coverage through Delta Dental and vision coverage through VSP.
  • 401k with match
  • Discretionary time off in addition to a 2 shutdowns per year (summer and winter) and additional company holidays
  • Complementary Long- and Short-Term Disability and Life Insurance
  • Monthly Cell Phone reimbursement
  • Free parking, monthly subway pass or subsidized commuter rail pass

Rheos Medicines is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Rheos Medicines complies with applicable state and local laws governing nondiscrimination in employment.


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