Senior Research Associate/Principal Research Assoc

Cambridge, MA
November 26, 2019

The Role

The Senior Research Associate/Principal Research Associate, Lead Discovery, will develop, implement, and execute appropriate cellular-based assays in support of drug discovery projects. The ideal candidate will be required to utilize a diverse set of cellular immunology and biochemical techniques to support lead discovery and profile small molecule chemical matter.


  • Ability to work in a matrixed organization while parallel processing several key activities simultaneously
  • Design and optimize cellular assays to evaluate small molecule inhibitors in support of drug discovery projects at Rheos 
  • Generate and maintain relevant cell lines for compound profiling and screening
  • Demonstrate target engagement of prioritized compounds in a cellular environment
  • Generate SOP documents
  • Manage uploading of data to an internal database
  • Work cross-functionally by communicating experimental results and conclusions within the Lead Discovery and Biology groups


  • A BS/MS degree in cell and/or molecular biology with 2 – 5 years drug discovery experience
  • Knowledge of the drug discovery process, with the ability to plan and troubleshoot difficult problems in cellular biology
  • Experience in generating cellular reagents in support of cell-based activity assays
  • Experience with developing cell-based assays to enable lead optimization of small molecules
  • Biochemical assay experience (mechanistic enzymology/high-throughput screening) is considered an advantage
  • Can-do attitude and team player with strong organizational, interpersonal, verbal and written communication skills
  • Experience with external collaborations (CROs) is an advantage, but not required

Apply Now

At Rheos, the well-being of our employees and their families is important to us.  We offer comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of our employees and their families.

Note to Recruitment Agencies: Please do not forward any agency resumes. Rheos Medicine is not responsible for any fees related to resumes that are unsolicited.


Equal Opportunity Employer M/F/D/V.

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