Careers

Senior/Principal Research Associate, Biology

Cambridge, MA
November 19, 2019


The Role

Responsible for initiating, designing and developing new scientific projects relevant to different immune related diseases. Ability to also perform a variety of immune based in vitro assays including both cellular and molecular biology techniques. Familiar with in vivo murine models.


Major Responsibilities

 

  • Responsible for developing in vitro immunological assays in relevant immune mediated diseases
  • Support scientists in developing new assays for example; setting up of mixed lymphocyte reactions, Treg suppression assays, in vitro cytotoxicity assays and projects
  • Independently design, execute studies and perform data analyses
  • Partner with bioinformatics and metabolism scientists to analyze and interpret data to generate novel hypothesis and validate targets for modulation of immune cell functions
  • Establish novel technologies / platforms for interrogating immune cells in human patient tissues
  • Participate in drug-discovery efforts including developing novel assays for compound screening or biomarker identification 
  • Test and implement cutting edge technologies such as Seahorse Bioflux analyses to drug new targets


Requirements

Requirements and Qualifications:

 

Education and Training:

Bachelors in Cellular and Molecular Immunology, cancer biology or Biochemistry with 5-8 years OR MS with 2-5 years’ with relevant and extensive experience in immunology research and development in the Biotech industry

 

Required Experience:

  • Experience in Immune cell biology and/or biochemistry conducting high quality science in an industry setting.
  • Experience in western blotting, ELISA, and MSD
  • Previous experience working and/or knowledge of mouse models, CRO management is a plus. 
  • Experience with data analysis including Prism and FlowJo
  • Experience working in a cross-functional matrixed organization.
  • Prior experience or track record in Immunometabolism a huge plus

Knowledge, Skills & Abilities:

  • Strong core competencies in molecular biology, cell biology and assay development
  • Proficiency in primary immune cell isolation and culture
  • Strong expertise in genetic manipulation using technologies such as CRISPR, shRNA, lentiviral/retroviral transduction, RNAi
  • Hands-on knowledge of flow cytometry and FACS analysis techniques
  • Ability to design and develop independent projects
  • Ability to be creative and apply a wide variety of scientific concepts and innovate and solve problems

 

 

Apply Now

At Rheos we endeavor to create an environment where great people have the opportunity to do great things.  We are pioneering new science and that takes creativity, innovation, integration and lots of teamwork to solve complex challenges.  We are risk takers and desire that our work at Rheos creates a new paradigm for immune-mediated diseases.

A highlight of our current benefit offerings:

  • Highly competitive healthcare coverage through Blue Cross Blue Shield, dental coverage through Delta Dental and vision coverage through VSP.
  • 401k with match
  • Discretionary time off in addition to a 2 shutdowns per year (summer and winter) and additional company holidays
  • Complementary Long- and Short-Term Disability and Life Insurance
  • Monthly Cell Phone reimbursement
  • Free parking, monthly subway pass or subsidized commuter rail pass

Rheos Medicines is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Rheos Medicines complies with applicable state and local laws governing nondiscrimination in employment.

 

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