Careers

Director, Discovery Biology

Cambridge, MA
October 11, 2019

The Company:

Rheos Medicines is a biopharmaceutical company developing novel medicines that modulate immune cell metabolism with an initial focus on treating patients with severe autoimmune diseases and cancer. We are rapidly applying a first-in-field approach in immunometabolism with a comprehensive, systems-biology understanding of the metabolic pathways that drive immune cell function. Launched in 2018 by Third Rock Ventures and pioneers in the field, Rheos is built on groundbreaking science, and our passionate team of more than 30 employees is advancing a novel pipeline of immunometabolism drugs.  We have brought together leading scientists whose discoveries opened the field of immunometabolism, clinicians with a deep understanding of the heterogeneity of immune-mediated diseases, and an experienced leadership team.


The Role:

The Director, Discovery Biology will manage a small group of scientists to drive target discovery and validation efforts as well as develop translational strategies for our early programs. Key responsibilities of this role are to develop research strategies and execute on plans to evaluate and validate targets to modulate immune cell function.  Working in cross-functional teams and management of laboratory scientists will be required to generate data in support of development decisions.


Responsibilities:

  • Maintains and conveys in-depth knowledge of fundamentals of immune mediated diseases
  • Oversees scientists as a group lead and works with the leadership team to ensure execution of in-vitro and in-vivo assays to validate new targets for advancement into portfolio and through drug-discovery stage gates
  • Assists in developing and maintaining group budget and workforce plan 
  • Represents pre-clinical and translational development in cross-functional project and strategy teams 
  • Assists in managing key strategic and/or collaborative projects with external partners
  • Communicates regularly and prepares and makes presentations within the department, externally, and to the company
  • Works with VP, Biology to integrate new target research into the overall corporate strategy


Qualifications:

  • Ph.D. degree in immunology, cellular biology or pharmacology
  • At least 10 years of relevant work experience, including a minimum of 5 years of drug development experience in the biotechnology or pharmaceutical industrial setting as evidenced by a strong publication record, attendance and presentation at scientific meetings, and recognition by industry peers
  • Track record in large and small companies, leading innovative efforts to deploy technologies and assays for enhanced translational capabilities
  • Excellent communication, managerial, and scientific qualities are expected
  • Ability to interact effectively across boundaries using influencing and relationship building skills
  • Competence in analysis and solving of problems, and the ability to prioritize and make tradeoffs to achieve goals
  • Experience in cell signaling and/or cellular metabolism is a plus

 

Technical Skills

  • In-depth understanding of autoimmune and inflammatory diseases, clinical landscape, evolving therapy, competitive scenario
  • Strong understanding of clinical, translational and mechanistic data of immunomodulatory therapies
  • Strong background in target discovery, pre-clinical validation, in vitro and in vivo platforms and assays
  • Good understanding of drug development process in an industry setting
  • Strong verbal and written communication skills with experience in developing written documents such as primary manuscripts/publications/reviews, disease strategies, mechanism slides, literature/market/patient segment analyses
  • Proven scientific/project leadership expertise (working in teams, managing collaborations, people/projects)
  • Ability to synthesize complex scientific and business problems into strategy and tactics

 

Other Attributes:

  • A problem solver who creatively and knowledgeably transcends departmental function to act as a resource to entire research effort
  • Identifies issues early and proposes innovative solutions
  • Communicates within the larger organization and external community
  • Provides expert guidance to multi-disciplinary teams and senior management
  • A leader who influences external scientific community

 

 

Requirements


Apply Now

At Rheos, the well-being of our employees and their families is important to us.  We offer comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of our employees and their families.

Note to Recruitment Agencies: Please do not forward any agency resumes. Rheos Medicine is not responsible for any fees related to resumes that are unsolicited.

 

Equal Opportunity Employer M/F/D/V.

Back to Top