Sr.RA/Associate Scientist, Lead Discovery

Cambridge, MA
June 12, 2019

The Role:

The Senior Research Associate/Associate Scientist, Lead Discovery, will provide essential support to small molecule drug discovery programs through the development and utilization of in vitro biochemical assays.  The ideal candidate will employ a variety of biochemical/biophysical techniques to develop enzymatic assays and validate small molecule chemical matter.


  • Ability to work in a matrixed organization while parallel processing several key activities simultaneously
  • Develop enzymatic assays to support Rheos’s drug discovery pipeline, including high-throughput screening and selectivity panels
  • Assess activity and substrate specificity for enzyme preparations    
  • Utilize biochemical/biophysical assays to prioritize/validate screening hits
  • Generate SOP documents
  • Manage uploading of data to an internal database


  • Requirements and Qualifications:
  • BS/MS degree with 5 – 10 years drug discovery experience in a pharmaceutical/biotechnology setting with a focus on biochemistry and mechanistic enzymology.
  • Knowledge of the drug discovery process, with the ability to plan and troubleshoot problems arising in biochemical assay development/screening. 
  • Experience with implementing a variety of assay formats, such as TR-FRET, AlphaLISA, FP, Radiometric, Luminescence, Mass Spectrometry (RapidFire), etc.
  • Experience with external collaborations (CROs) is an advantage, but not required.
  • Can-do attitude and team player with strong organizational, interpersonal, verbal and written communication skills.

Apply Now

At Rheos, the well-being of our employees and their families is important to us.  We offer comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of our employees and their families.

Note to Recruitment Agencies: Please do not forward any agency resumes. Rheos Medicine is not responsible for any fees related to resumes that are unsolicited.


Equal Opportunity Employer M/F/D/V.

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