Senior Research Associate

Cambridge, MA
April 04, 2019

The Role

This is an exciting opportunity to join a growing company and have a direct impact on the immuno-oncology science we are doing to advanacen our broader immunometabolism drug pipleline. This person will be responsible for initiating, designing and developing new scientific projects relevant to immuno-oncology. The ideal candidate will have the ability to perform a variety of immune based in vitro assays including both cellular and molecular biology techniques.


Major Responsibilities


  • Responsible for developing in vitro and in vivo immunological assays for immuno-oncology
  • Support scientists in developing new assays including the setting up of mixed lymphocyte reactions, Treg suppression assays, in vitro cytotoxicity assays and projects
  • Independently design, execute studies and perform data analyses
  • Partner with bioinformatics and metabolism scientists to analyze and interpret data to generate novel hypothesis and validate targets for modulation of immune cell functions
  • Establish novel technologies and platforms for interrogating immune cells in human patient tissues
  • Participate in drug-discovery efforts including developing novel assays for compound screening or biomarker identification
  • Test and implement cutting edge technologies such as Seahorse Bioflux analyses to drug new targets


Requirements and Qualifications:


Education and Training:

Bachelors degree in cellular and molecular immunology, cancer biology or biochemistry with 5-8 years experience OR MS with 2-5 years’ with relevant and extensive experience in immuno-oncology research and development in a biotech industry setting.


Required Experience:

  • Extensive experience in in vitro immune based assays in isolating, differentiating, culturing and profiling immune cell subsets of both innate and adaptive immunity or various other non-immune cell types.
  • Relevant industry experience and working with cross-functional matrixed project teams


Knowledge, Skills & Abilities:

  • Ability to design and develop independent projects
  • Ability to be creative and apply a wide variety of scientific concepts, innovate and solve problems
  • Design and execution of methods to support platform and program development including assays for characterizing target expression/engagement
  • Ability to prepare technical reports to support process development/IND filing


Preferred additional Knowledge & Experience:


  • Hands-on experience with human immunology strongly preferred 
  • Familiarity with and hands on experience in in vivo murine models of immune related diseases desired
  • Capability to develop in vivo models relevant for immune-oncology
  • Understanding and experience with immunometabolic techniques such as Seahorse Bioflux analyses would be a strong plus.
  • Prior experience or track record in Immunometabolism a huge plus



Apply Now

At Rheos, the well-being of our employees and their families is important to us.  We offer comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of our employees and their families.

Note to Recruitment Agencies: Please do not forward any agency resumes. Rheos Medicine is not responsible for any fees related to resumes that are unsolicited.


Equal Opportunity Employer M/F/D/V.

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