Associate Director, Structural Biology

Cambridge, MA
April 03, 2019

The Role:


The Associate Director, Structural Biology, will provide leadership and expertise in the structural characterization of Rheos’s drug targets. The ideal candidate will be focused on protein crystallography but will integrate with the drug discovery organization to implement a variety of biophysical techniques.


Major Responsibilities


  • Collaborate with colleagues in lead discovery, biology, and chemistry to develop a structural biology strategy.
  • Designing biophysics-grade protein constructs and assisting in the optimization of purification protocols.
  • Crystallization, X-ray structure determination, and analysis of important drug targets through working with external collaborators.
  • Management of external structural biology collaborations (CROs)
  • Providing regular updates to cross-functional teams and helping guide structure-based compound design in close collaboration with chemistry group.


Requirements and Qualifications



  • PhD degree structural biology or biophysics


Required Experience:

  • 7+ years of drug discovery experience in a pharmaceutical/biotechnology setting;
  • Demonstrated ability to solve difficult problems in protein crystallography, structural biology and biophysics
  • Demonstrated competency in protein construct design and expression and purification strategies using bacterial, insect, and mammalian hosts.


Knowledge, Skills & Abilities:


  • Strong knowledge of the drug discovery process, with deep experience in implementing hit identification strategies through candidate selection;
  • Extensive knowledge of protein structure and function, with the ability to articulately communicate structural information to a broad audience.
  • Experience with other structural techniques (e.g. electron microscopy, small-angle X-ray scattering) is preferred.


Apply Now

At Rheos, the well-being of our employees and their families is important to us.  We offer comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of our employees and their families.

Note to Recruitment Agencies: Please do not forward any agency resumes. Rheos Medicine is not responsible for any fees related to resumes that are unsolicited.


Equal Opportunity Employer M/F/D/V.

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