Unmet Needs in Immune‑mediated Diseases

Unmet Needs in Immune‑mediated Diseases

The immune system plays a role in chronic inflammation, autoimmune diseases and cancer. Despite advances, there remains a great unmet need for millions of patients. Targeting cellular metabolism of immune cells opens a tremendous opportunity to progress beyond current treatments and pursue new precision approaches to immune-mediated diseases.

Today, a more in-depth understanding of the immune system and its many cell types and functions is emerging based upon research by leading academic scientists, including Rheos’s founders. It is now possible to investigate a fundamentally new approach to treat immune-mediated diseases which consider the full range of immune cells and their functions and how they are regulated by cellular metabolism. In addition, by simultaneously identifying new therapeutic targets and related biomarkers, it is possible to address the heterogeneity of many immune-mediated disorders and bring precision to their treatment.

Fine-tuning the Immune Response

The human immune system integrates multiple cell types with activating and suppressive functions. We now appreciate the activating and suppressive functions exhibit a high-degree of plasticity which offers the opportunity to tune fate and function. By tuning the fate and function of these immune cells, we can redirect the diseased immune system back to healthy function.

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