Tuning Immune Cell Fate and Function

Tuning Immune Cell Fate and Function

At Rheos, we are developing new drugs that tune the immune system by directing the maturation and function of specific immune cells. We intend to bring precision to the treatment of immune-mediated diseases by concurrently identifying new therapeutic targets and biomarkers of disease.

Just like any other cell in the body, immune cells require nutrients such as sugar, proteins or fat to generate energy to support their activities, including maturation, function and survival. Nutrients are converted to cellular building blocks, and then utilized through different sequences of metabolic reactions, often referred to as a metabolic pathway. Recent scientific discoveries have demonstrated the pivotal role that metabolic pathways play in directing and sustaining immune cell maturation and function, and thus, overall immune responses.1

Our molecules selectively regulate immunometabolism, or the cellular metabolism of immune cell populations, in order to redirect their fate and function and ultimately rebalance a dysregulated immune response.

1Pearce EJ and Pearce EL. January 2018, Nature Reviews Immunology 18, 81–82.

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