Position Details
Date Posted:
March 18, 2021
Location:
Cambridge, MA
Description:
The Role
The Research Associate / Senior Research Associate will develop & implement appropriate assays and systems required for the identification & validation of targets for autoimmune/inflammatory diseases, advancement of high priority projects, as well as the company’s product engine.
Responsibilities
- Development and implementation of a diverse set of cellular/molecular immunology assays and systems
- Design and execution of experiments used to identify and validate potential drug targets for autoimmune and inflammatory diseases
- Participation in planning and troubleshooting of experiments to support project goals
- Partner with scientific leadership design, execute, troubleshoot, and interpret biological experiments in support of program objectives
- Develop protocols for diverse assays
- Maintain accurate documentation of experiments
- Interact and communicate results and conclusions within the biology group and cross functional project teams
- Review the scientific literature, attend user groups, to remain abreast of developments in relevant fields
Requirements:
- BS or MS in immunology, cell and/or molecular biology, or pharmacology
- Minimum of 2-5 years of hands on experience in cellular and molecular immunology techniques such as flow cytometry, Western blots, ELISA, qPCR
- Experience in purification and/or culturing of immune cells such as lymphocytes, monocytes, macrophages, neutrophils; experience with primary human cells a plus
- Experience with the ability to assess target biology with genetic perturbation techniques such as CRISPR-Cas9, shRNA, lentiviral/retroviral transduction, RNAi
- Experience with data logging in electronic notebooks as well as the use of visualization software and associated analysis of rich cellular datasets.
- Effective Communication of results and conclusions
- Demonstrated ability to thrive in a team environment
- Ability to function equally well in self-starter mode, as well as, a member of a matrixed team
- Strong experimental background and a rigorous, analytical approach to problem solving
- Experience in working with other cell types such as synovial fibroblasts, dermal fibroblasts, keratinocytes, DCs