December 24, 2020
Senior Research Associate / Associate Scientist is responsible for initiating, designing and developing new scientific projects relevant to different immune related diseases. Ability to also perform a variety of immune based in vitro assays including both cellular and molecular biology techniques. Familiar with in vivo murine models.
- Responsible for developing in vitro immunological assays in relevant immune mediated diseases
- Support scientists in developing new assays for example; setting up of mixed lymphocyte reactions, Treg suppression assays, in vitro cytotoxicity assays and projects
- Independently design, execute studies and perform data analyses
- Partner with bioinformatics and metabolism scientists to analyze and interpret data to generate novel hypothesis and validate targets for modulation of immune cell functions
- Establish novel technologies / platforms for interrogating immune cells in human patient tissues
- Participate in drug-discovery efforts including developing novel assays for compound screening or biomarker identification
- Test and implement cutting edge technologies such as Seahorse Bioflux analyses to drug new targets
- Bachelors in Cellular and Molecular Immunology, cancer biology or Biochemistry with 5-8 years OR MS with 2-5 years’ with relevant and extensive experience in immunology research and development in the Biotech industry
- Experience in Immune cell biology and/or biochemistry conducting high quality science in an industry setting.
- Experience in western blotting, ELISA, and MSD
- Previous experience working and/or knowledge of mouse models, CRO management is a plus.
- Experience with data analysis including Prism and FlowJo
- Experience working in a cross-functional matrixed organization.
- Prior experience or track record in Immunometabolism a huge plus
- Strong core competencies in molecular biology, cell biology and assay development
- Proficiency in primary immune cell isolation and culture
- Strong expertise in genetic manipulation using technologies such as CRISPR, shRNA, lentiviral/retroviral transduction, RNAi
- Hands-on knowledge of flow cytometry and FACS analysis techniques
- Ability to design and develop independent projects
- Ability to be creative and apply a wide variety of scientific concepts and innovate and solve problems