Senior Research Associate / Associate Scientist, Biology

Position Details

Date Posted:

December 24, 2020

Location:

Cambridge, MA

Description:

The Role

Senior Research Associate / Associate Scientist is responsible for initiating, designing and developing new scientific projects relevant to different immune related diseases. Ability to also perform a variety of immune based in vitro assays including both cellular and molecular biology techniques. Familiar with in vivo murine models.

Responsibilities

  • Responsible for developing in vitro immunological assays in relevant immune mediated diseases
  • Support scientists in developing new assays for example; setting up of mixed lymphocyte reactions, Treg suppression assays, in vitro cytotoxicity assays and projects
  • Independently design, execute studies and perform data analyses
  • Partner with bioinformatics and metabolism scientists to analyze and interpret data to generate novel hypothesis and validate targets for modulation of immune cell functions
  • Establish novel technologies / platforms for interrogating immune cells in human patient tissues
  • Participate in drug-discovery efforts including developing novel assays for compound screening or biomarker identification
  • Test and implement cutting edge technologies such as Seahorse Bioflux analyses to drug new targets

Requirements:

  • Bachelors in Cellular and Molecular Immunology, cancer biology or Biochemistry with 5-8 years OR MS with 2-5 years’ with relevant and extensive experience in immunology research and development in the Biotech industry
  • Experience in Immune cell biology and/or biochemistry conducting high quality science in an industry setting.
  • Experience in western blotting, ELISA, and MSD
  • Previous experience working and/or knowledge of mouse models, CRO management is a plus.
  • Experience with data analysis including Prism and FlowJo
  • Experience working in a cross-functional matrixed organization.
  • Prior experience or track record in Immunometabolism a huge plus
  • Strong core competencies in molecular biology, cell biology and assay development
  • Proficiency in primary immune cell isolation and culture
  • Strong expertise in genetic manipulation using technologies such as CRISPR, shRNA, lentiviral/retroviral transduction, RNAi
  • Hands-on knowledge of flow cytometry and FACS analysis techniques
  • Ability to design and develop independent projects
  • Ability to be creative and apply a wide variety of scientific concepts and innovate and solve problems