Scientist II Biology

Position Details

Date Posted:

September 23, 2020

Location:

Cambridge, MA

Description:

The Role

Responsible for identification of and evaluating mechanism of action of novel targets to inform therapeutic potential in autoimmune and inflammatory diseases.  Ability to conceive and perform a variety of immune-based & inflammatory disease-state in vitro assays including both cellular and molecular biology systems to address target-specific hypotheses. Background in cell signaling &/or immunometabolism a plus.  Working within an integrated team will be essential for success.

 

Responsibilities

  • Responsible for developing in vitro assays & systems relevant to autoimmune or inflammatory diseases
  • Independently design, execute studies and perform data analyses
  • Partner with bioinformatics and metabolism scientists to design experiments and analyze and interpret data
  • Generate novel hypotheses and validate targets for modulation of immune cell/disease-relevant cell function
  • Innovate and establish novel technologies/platforms for interrogating immune (& other) cells in relevant microenvironments and in human patient samples
  • Participate in drug discovery efforts including developing novel assays for compound screening and/or biomarker identification
  • Effective Communication of results and conclusions
  • Participation in planning and troubleshooting of experiments to support project goals
  • Potential to supervise and mentor junior research staff

Requirements:

  • Ph.D. Cellular and Molecular Immunology, Biochemistry
  • 1-2 years of Postdoctoral experience in immunology or immunometabolism
  • 2-5 years experience in research and development environment (industry experience a plus)
  • Extensive experience with in vitro immune-based assays in isolating, differentiating, culturing, assessing activity, and profiling primary human immune cells including monocytes/macrophages. Experience with synovial fibroblasts, dermal fibroblasts, keratinocytes and cell types of both innate and adaptive immunity a plus.
  • Experience with flow cytometry (experiment design, setting instrument through data analysis)
  • Prior experience or track record in immunometabolism &/or cell signaling a
  • Prior experience with CRISPR technology a plus
  • Ability to design, develop, & execute experimental plans for independent projects
  • Creatively apply a wide variety of scientific concepts to solve complex problems
  • Strong experimental background and a rigorous, analytical approach to problem solving
  • Experience with data logging in electronic notebooks as well as the use of visualization software and associated analysis of rich cellular datasets.
  • Working with highly collaborative matrixed project teams critical for success
  • Flexibility to work on multiple independent programs
  • Prior management experience directing research associates will be important
  •  In partnership with scientific leadership design, execute, troubleshoot, and interpret biological experiments in support of program objectives
  • Develop protocols for diverse assays
  • Maintain accurate documentation of experiments
  • Interact and communicate results and conclusions within the biology group and cross functional project teams
  • Review the scientific literature, attend user groups, to remain abreast of developments in relevant fields
  • Ability to function equally well in self-starter mode, as well as, a member of a matrixed team