Scientist II, Biology

Position Details

Date Posted:

September 23, 2020


Cambridge, MA


The Role

Responsible for identification of and evaluating mechanism of action of novel targets to inform therapeutic potential in autoimmune and inflammatory diseases.  Ability to conceive and perform a variety of immune-based & inflammatory disease-state in vitro assays including both cellular and molecular biology systems to address target-specific hypotheses. Background in cell signaling &/or immunometabolism a plus.  Working within an integrated team will be essential for success.



  • Responsible for developing in vitro assays & systems relevant to autoimmune or inflammatory diseases
  • Independently design, execute studies and perform data analyses
  • Partner with bioinformatics and metabolism scientists to design experiments and analyze and interpret data
  • Generate novel hypotheses and validate targets for modulation of immune cell/disease-relevant cell function
  • Innovate and establish novel technologies/platforms for interrogating immune (& other) cells in relevant microenvironments and in human patient samples
  • Participate in drug discovery efforts including developing novel assays for compound screening and/or biomarker identification
  • Effective Communication of results and conclusions
  • Participation in planning and troubleshooting of experiments to support project goals
  • Potential to supervise and mentor junior research staff


  • Ph.D. Cellular and Molecular Immunology, Biochemistry
  • 1-2 years of Postdoctoral experience in immunology or immunometabolism
  • 2-5 years experience in research and development environment (industry experience a plus)
  • Extensive experience with in vitro immune-based assays in isolating, differentiating, culturing, assessing activity, and profiling primary human immune cells including monocytes/macrophages. Experience with synovial fibroblasts, dermal fibroblasts, keratinocytes and cell types of both innate and adaptive immunity a plus.
  • Experience with flow cytometry (experiment design, setting instrument through data analysis)
  • Prior experience or track record in immunometabolism &/or cell signaling a
  • Prior experience with CRISPR technology a plus
  • Ability to design, develop, & execute experimental plans for independent projects
  • Creatively apply a wide variety of scientific concepts to solve complex problems
  • Strong experimental background and a rigorous, analytical approach to problem solving
  • Experience with data logging in electronic notebooks as well as the use of visualization software and associated analysis of rich cellular datasets.
  • Working with highly collaborative matrixed project teams critical for success
  • Flexibility to work on multiple independent programs
  • Prior management experience directing research associates will be important
  •  In partnership with scientific leadership design, execute, troubleshoot, and interpret biological experiments in support of program objectives
  • Develop protocols for diverse assays
  • Maintain accurate documentation of experiments
  • Interact and communicate results and conclusions within the biology group and cross functional project teams
  • Review the scientific literature, attend user groups, to remain abreast of developments in relevant fields
  • Ability to function equally well in self-starter mode, as well as, a member of a matrixed team